BDBM50092310 CHEMBL3581661::US9675697, Cpd. No. 23

SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21

InChI Key InChIKey=WHDUHJYPRJXLGF-UHFFFAOYSA-N

Data  12 KI  2 IC50  21 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50092310   

TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM50092310(CHEMBL3581661 | US9675697, Cpd. No. 23)
Affinity DataKi:  3.20nM ΔG°:  -11.6kcal/moleT: 2°CAssay Description:Fluorescence Polarization (FP) competitive binding studies (see above) were carried out using the FAM labeled fluorescent probe Cpd. No. 350 to deter...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBromodomain-containing protein 3 [326-398](Homo sapiens (Human))
The Regents of The University of Michigan

US Patent
LigandPNGBDBM50092310(CHEMBL3581661 | US9675697, Cpd. No. 23)
Affinity DataKd:  21nMpH: 7.4Assay Description:Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...More data for this Ligand-Target Pair
In DepthDetails US Patent